Myelin formation
HIV dementia
Structural Proteins Drug-induced neuropathy
^ by ddI
and ddC
| Multiple
Sclerosis repair
--- > Methionine
<-- Diet
^ | Brain
injury repair, including
| | Physical trauma
| | Alzheimer’s damage
| |
+ ATP
| |
| |
| | Membrane
phospholipid methylation
| S-adenosyl-methionine affects Ca++ transport,
| | both into and out of cells
| | Cardiomyopathy
| | Pancreatitis | |
Demyelination
| |
| |
| | Neural
Tube Defects | | prevention
| |
| | ---> CH3
----->
| | Transcription inhibition of:
| | Latent virus
| | Oncogenes
| | HIV
| |
| | Senescense
gene expression
| | inhibition
| |
| | DNA and RNA synthesis
| | DNA
damage repair
| |
| S-adenosyl-homocysteine Lecithin formation
| | lipid transport
| | ---> adenosine
^ |
+ <-- Homocysteine Cardiovascular disease
^ | risk
factor
| |
| |
| | Pernicious
Anemia
| |
|------<
CH3 <--- B12 <--- Folate <--- Serine <--- Glucose
|
|------<
CH3 <--- Betaine <--- Choline <--- Triglycerides
Homocysteine Decrease
blood glucose
| by
increasing liver
| ---+
serine < Glucose intracellular
utilization
| +
B6 of glucose
|
|
Cystathionine Hyperhomocysteinurics
cannot make
| cystathionine
|
| <------------- Stress block here
|
| + B6 Structural
Protein formation
|
| Albumin
fragmentation prevention
|
Cysteine --->
SH groups Arthritis (free
sulfhydral repletion)
|
| HIV (sulfhydral repletion)
|
| Alzheimer’s
(brain sulfhydral repletion)
|
| Total
Parenteral Nutrition (cysteine
repletion)
|
|
| Reducing Equivalent supply
|
+ glycine Oxidative
damage prevention
| + glutamic acid HIV transcription inhibition
| ----> Glutathione Heavy metal chelation and elimination
| Sunburn
damage inhibition
| Modulate
Nitric Oxide effects in cardiomyopathy
|
|
Sulfate + ATP Mucus formation
| ---> Phospho- Collagen formation, wound
healing , burn treatment
|
Adenosine Detoxification
and elimination of drugs
| Phospho- Sulfolipid formation
| Sulfate Cartilage repair
|
|
|
Urinary Sulfate Kidney stone
formation inhibition
Measurement
of methionine intake
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